Products-Topo Biotechnology Co., Ltd.Plant Molecular Extraction

Topo Biotechnology Co., Ltd.

PRODUCTS

Project Background

• Active screening of plant ingredients is a source of new drug discovery.
• Plants have been screened for high abundance components-resource depletion, low probability of new drug discovery, high cost.
• Components of low abundance in plants missed screening (false negatives) in the past because they were below the detection line.
• By enriching the low-abundance components, new drugs can be developed from screened plants where no new drugs have been found.

Industry pain points

The difficulties in extracting trace natural compounds

Laboratory-scale separation techniques for trace components cannot yield the quantity required for new drug development.

The dead adsorption phenomenon of trace components of natural compounds on chromatographic separation media turns the separation process into an abundance-reducing one, resulting in the loss of trace components.

Technical comparison

At present, the important equipment in the world is the laboratory level automation integration.

Tuopu Company is a systematic innovation at the level of industrialization.

1, Industrialized separation technology of natural compound components

2. Enrichment technology of low abundance natural compounds
Technology 1 Application:The complex mixture is separated from the natural extract into fractions containing 5-7 components.
Technology and equipment:Component separation technology, industrial equipment.
Features:Kg separation, no dead adsorption in the process of component separation.
Technology 2 Application:Fractions obtained from Technique 1 are enriched in low-abundance components.
Technology and equipment:Enrichment technology, industrialization equipment.
Features:Kilogram enrichment, no dead adsorption in the enrichment process.

International and Domestic Large-scale Separation Technology of Natural Ingredients Sepbox
Sepbox is made in Germany. It is an HPLC two-dimensional chromatography technology. It is connected by a solid phase extraction small column between the first and second-dimensional chromatographic columns. It can separate 2 grams of extract per day and obtain hundreds of fractions.
Features:

1, the fraction still needs to prepare high-efficiency liquid phase separation monomer components.
2, can not achieve trace component enrichment.
3, is still a laboratory technology, can not solve
Problems with the separation of low abundance components.